Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit

Zinc is abundant in the central nervous system and regulates pain, but the underlying mechanisms are unknown. In vitro studies have shown that extracellular zinc modulates a plethora of signaling membrane proteins, including NMDA receptors containing the NR2A subunit, which display exquisite zinc se...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Nozaki, Chihiro, Vergnano, Angela Maria, Filliol, Dominique, Ouagazzal, Abdel-Mouttalib, Le Goff, Anne, Carvalho, Stéphanie, Reiss, David, Gaveriaux-Ruff, Claire, Neyton, Jacques, Paoletti, Pierre, Kieffer, Brigitte L
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494785/
https://ncbi.nlm.nih.gov/pubmed/21725314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2844
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