Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation

Lassa virus (LASV) causes a severe, often fatal, hemorrhagic fever endemic to West Africa. Presently, there are no FDA-licensed medical countermeasures for this disease. In a pilot study, we constructed a DNA vaccine (pLASV-GPC) that expressed the LASV glycoprotein precursor gene (GPC). This plasmid...

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Veröffentlicht in:Vaccines (Basel)
Hauptverfasser: Cashman, Kathleen A., Broderick, Kate E., Wilkinson, Eric R., Shaia, Carl I., Bell, Todd M., Shurtleff, Amy C., Spik, Kristin W., Badger, Catherine V., Guttieri, Mary C., Sardesai, Niranjan Y., Schmaljohn, Connie S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494234/
https://ncbi.nlm.nih.gov/pubmed/26344112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines1030262
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