DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant

Eliciting effective immune responses using non-living/replicating DNA vaccines is a significant challenge. We have previously shown that ballistic dermal plasmid DNA-encoded flagellin (FliC) promotes humoral as well as cellular immunity to co-delivered antigens. Here, we observe that a plasmid encod...

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Veröffentlicht in:Vaccines (Basel)
Hauptverfasser: Nyström, Sanna, Bråve, Andreas, Falkeborn, Tina, Devito, Claudia, Rissiek, Björn, Johansson, Daniel X., Schröder, Ulf, Uematsu, Satoshi, Akira, Shizuo, Hinkula, Jorma, Applequist, Steven E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494208/
https://ncbi.nlm.nih.gov/pubmed/26344341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines1040415
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