Polymorphism Analysis Reveals Reduced Negative Selection and Elevated Rate of Insertions and Deletions in Intrinsically Disordered Protein Regions

Intrinsically disordered protein regions are abundant in eukaryotic proteins and lack stable tertiary structures and enzymatic functions. Previous studies of disordered region evolution based on interspecific alignments have revealed an increased propensity for indels and rapid rates of amino acid s...

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Bibliographic Details
Published in:Genome Biol Evol
Main Authors: Khan, Tahsin, Douglas, Gavin M., Patel, Priyenbhai, Nguyen Ba, Alex N., Moses, Alan M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494057/
https://ncbi.nlm.nih.gov/pubmed/26047845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evv105
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