The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium

Mutations in RPGRIP1L result in severe human diseases called ciliopathies. To unravel the molecular function of RPGRIP1L, we analyzed Rpgrip1l(−/−) mouse embryos, which display a ciliopathy phenotype and die, at the latest, around birth. In these embryos, cilia-mediated signaling was severely distur...

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Publicado en:J Cell Biol
Autores principales: Gerhardt, Christoph, Lier, Johanna Maria, Burmühl, Stephan, Struchtrup, Andreas, Deutschmann, Kathleen, Vetter, Maik, Leu, Tristan, Reeg, Sandra, Grune, Tilman, Rüther, Ulrich
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2015
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494006/
https://ncbi.nlm.nih.gov/pubmed/26150391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201408060
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