Multi-Trial Evaluation of Progression-Free Survival (PFS) as a Surrogate Endpoint for Overall Survival (OS) in First-Line Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

INTRODUCTION: We previously reported that PFS may be a candidate surrogate endpoint for OS in first-line ES-SCLC using data from 3 randomized trials (Foster, Cancer 2011). In this validation study (N0424-Alliance), we assessed the patient- and trial-level surrogacy of PFS using data from 7 new first...

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Detalhes bibliográficos
Publicado no:J Thorac Oncol
Main Authors: Foster, Nathan R., Renfro, Lindsay A., Schild, Steven E., Redman, Mary W., Wang, Xiaofei F., Dahlberg, Suzanne E., Ding, Keyue, Bradbury, Penelope A., Ramalingam, Suresh S., Gandara, David R., Shibata, Taro, Saijo, Nagahiro, Vokes, Everett E., Adjei, Alex A., Mandrekar, Sumithra J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493926/
https://ncbi.nlm.nih.gov/pubmed/26134227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000548
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