Nrf2 Deficiency Promotes Apoptosis and Impairs Pax7/MyoD Expression in Aging Skeletal Muscle Cells

Skeletal muscle redox homoeostasis is transcriptionally regulated by nuclear erythroid-2-p45-related factor-2 (Nrf2). We recently demonstrated that age-associated stress impairs Nrf2-ARE (antioxidant response element) transcriptional signaling. Here, we hypothesize that age-dependent decline or gene...

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Detalles Bibliográficos
Publicado en:Free Radic Biol Med
Main Authors: Narashimhan, Madhusudhanan, Hong, Jennifer, Atieno, Nancy, Muthusamy, Vasanthi R., Davidson, Christopher J., Abu-Rmaileh, Naser, Richardson, Russell, Gomes, Aldrin V., Hoidal, John R., Rajasekaran, Namakkal S.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493911/
https://ncbi.nlm.nih.gov/pubmed/24613379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.02.023
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