Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy

AIMS: Mutant protein aggregation (PA) cardiomyopathy (MPAC) is characterized by reductive stress (RS), PA (of chaperones and cytoskeletal components), and ventricular dysfunction in transgenic mice expressing human mutant CryAB (hmCryAB). Sustained activation of nuclear erythroid-2 like factor-2 (Nr...

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Autors principals: Kannan, Sankaranarayanan, Muthusamy, Vasanthi R., Whitehead, Kevin J., Wang, Li, Gomes, Aldrin V., Litwin, Sheldon E., Kensler, Thomas W., Abel, E. Dale, Hoidal, John R., Rajasekaran, Namakkal S.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778956/
https://ncbi.nlm.nih.gov/pubmed/23761402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvt150
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