Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy

AIMS: Mutant protein aggregation (PA) cardiomyopathy (MPAC) is characterized by reductive stress (RS), PA (of chaperones and cytoskeletal components), and ventricular dysfunction in transgenic mice expressing human mutant CryAB (hmCryAB). Sustained activation of nuclear erythroid-2 like factor-2 (Nr...

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Autori principali: Kannan, Sankaranarayanan, Muthusamy, Vasanthi R., Whitehead, Kevin J., Wang, Li, Gomes, Aldrin V., Litwin, Sheldon E., Kensler, Thomas W., Abel, E. Dale, Hoidal, John R., Rajasekaran, Namakkal S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778956/
https://ncbi.nlm.nih.gov/pubmed/23761402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvt150
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