Effect of Colesevelam on Fecal Bile Acids and Bowel Functions in Diarrhea-Predominant Irritable Bowel Syndrome

BACKGROUND: About one-third of patients with IBS-diarrhea (IBS-D) have evidence of increased bile acid (BA) synthesis or excretion. AIMS: To assess effects of the BA sequestrant, colesevelam, on fecal excretion of BAs, hepatic BA synthesis and diarrhea in IBS-D; to appraise whether individual or ran...

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Udgivet i:Aliment Pharmacol Ther
Main Authors: Camilleri, Michael, Acosta, Andres, Busciglio, Irene, Boldingh, Amy, Dyer, Roy B., Zinsmeister, Alan R., Lueke, Alan, Gray, Amber, Donato, Leslie J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493894/
https://ncbi.nlm.nih.gov/pubmed/25594801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.13065
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