Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination

DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the Smc5–Smc6 complex is recruited to DSBs de novo to support their repair by homologous reco...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: De Piccoli, Giacomo, Cortes-Ledesma, Felipe, Ira, Gregory, Torres-Rosell, Jordi, Uhle, Stefan, Farmer, Sarah, Hwang, Ji-Young, Machin, Felix, Ceschia, Audrey, McAleenan, Alexandra, Cordon-Preciado, Violeta, Clemente-Blanco, Andrés, Vilella-Mitjana, Felip, Ullal, Pranav, Jarmuz, Adam, Leitao, Beatriz, Bressan, Debra, Dotiwala, Farokh, Papusha, Alma, Zhao, Xiaolan, Myung, Kyungjae, Haber, James E., Aguilera, Andrés, Aragón, Luis
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493748/
https://ncbi.nlm.nih.gov/pubmed/16892052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1466
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