Generation of fertile offspring from Kit(w)/Kit(wv) mice through differentiation of gene corrected nuclear transfer embryonic stem cells

Genetic mutations could cause sperm deficiency, leading to male infertility. Without functional gametes in the testes, patients cannot produce progeny even with assisted reproduction technologies such as in vitro fertilization. It has been a major challenge to restore the fertility of gamete-deficie...

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Détails bibliographiques
Publié dans:Cell Res
Auteurs principaux: Yuan, Yan, Zhou, Quan, Wan, Haifeng, Shen, Bin, Wang, Xuepeng, Wang, Mei, Feng, Chunjing, Xie, Mingming, Gu, Tiantian, Zhou, Tao, Fu, Rui, Huang, Xingxu, Zhou, Qi, Sha, Jiahao, Zhao, Xiao-Yang
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493281/
https://ncbi.nlm.nih.gov/pubmed/26088417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.74
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