Generation of fertile offspring from Kit(w)/Kit(wv) mice through differentiation of gene corrected nuclear transfer embryonic stem cells

Genetic mutations could cause sperm deficiency, leading to male infertility. Without functional gametes in the testes, patients cannot produce progeny even with assisted reproduction technologies such as in vitro fertilization. It has been a major challenge to restore the fertility of gamete-deficie...

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Vydáno v:Cell Res
Hlavní autoři: Yuan, Yan, Zhou, Quan, Wan, Haifeng, Shen, Bin, Wang, Xuepeng, Wang, Mei, Feng, Chunjing, Xie, Mingming, Gu, Tiantian, Zhou, Tao, Fu, Rui, Huang, Xingxu, Zhou, Qi, Sha, Jiahao, Zhao, Xiao-Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493281/
https://ncbi.nlm.nih.gov/pubmed/26088417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.74
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