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Restore natural fertility of Kit(w)/Kit(wv) mouse with nonobstructive azoospermia through gene editing on SSCs mediated by CRISPR-Cas9

BACKGROUND: Male infertility is a serious social problem in modern society. Nonobstructive azoospermia (NOA) caused by germ cell gene defects is an important reason for male infertility, but effective clinical treatment for this disease has not been established. METHODS: We choose Kit(w)/Kit(wv) mou...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Li, Xiaoyu, Sun, Tiecheng, Wang, Xiuxia, Tang, Jixin, Liu, Yixun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708192/
https://ncbi.nlm.nih.gov/pubmed/31445521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1386-7
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