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Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency
INTRODUCTION: The pyruvate dehydrogenase (PDH) complex is localized in the mitochondrial matrix catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA and NADH. For proper complex regulation the E1-α subunit functions as an on/off switch regulated by phosphorylation/dephosphorylation....
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4493017/ https://ncbi.nlm.nih.gov/pubmed/26147621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131663 |
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