14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia

The down-modulation of the β-catenin antagonist Chibby 1 (CBY1) associated with the BCR-ABL1 fusion gene of chronic myeloid leukemia (CML) contributes to the aberrant activation of β-catenin, particularly in leukemic stem cells (LSC) resistant to tyrosine kinase (TK) inhibitors. It is, at least part...

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Publicat a:PLoS One
Autors principals: Mancini, Manuela, Leo, Elisa, Takemaru, Ken-Ichi, Campi, Virginia, Castagnetti, Fausto, Soverini, Simona, De Benedittis, Caterina, Rosti, Gianantonio, Cavo, Michele, Santucci, Maria Alessandra, Martinelli, Giovanni
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492953/
https://ncbi.nlm.nih.gov/pubmed/26147002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131074
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