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Mu Opioid Receptor Stimulation Activates c-Jun N-Terminal Kinase 2 by Distinct Arrestin-Dependent and Independent Mechanisms

G protein-coupled receptor desensitization is typically mediated by receptor phosphorylation by G protein receptor kinase (GRK) and subsequent arrestin binding; morphine, however, was previously found to activate a c-Jun N-Terminal Kinase (JNK)-dependent, GRK/arrestin-independent pathway to produce...

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Dettagli Bibliografici
Pubblicato in:Cell Signal
Autori principali: Kuhar, Jamie Rose, Bedini, Andrea, Melief, Erica J., Chiu, Yen-Chen, Striegel, Heather N., Chavkin, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492890/
https://ncbi.nlm.nih.gov/pubmed/26056051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2015.05.019
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