CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis

Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ovarian cancers. Multiple ovarian cancer cell lines...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:PLoS One
Autores principales: Zhang, Shu, Lu, Zhen, Mao, Weiqun, Ahmed, Ahmed A., Yang, Hailing, Zhou, Jinhua, Jennings, Nicholas, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Miranda, Roberto, Qiao, Wei, Baladandayuthapani, Veera, Li, Zongfang, Sood, Anil K., Liu, Jinsong, Le, Xiao-Feng, Bast, Robert C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492679/
https://ncbi.nlm.nih.gov/pubmed/26146988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131833
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares