The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts.

The widely prevailing view that the cyclin-dependent kinase inhibitors (CKIs) are solely negative regulators of cyclin-dependent kinases (CDKs) is challenged here by observations that normal up-regulation of cyclin D- CDK4 in mitogen-stimulated fibroblasts depends redundantly upon p21(Cip1) and p27(...

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Main Authors: Cheng, M, Olivier, P, Diehl, J A, Fero, M, Roussel, M F, Roberts, J M, Sherr, C J
格式: Artigo
語言:Inglês
出版: 1999
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171245/
https://ncbi.nlm.nih.gov/pubmed/10075928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.6.1571
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