Ad35.CS.01 - RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults

METHODS: In an observer blind, phase 2 trial, 55 adults were randomized to receive one dose of Ad35.CS.01 vaccine followed by two doses of RTS,S/AS01 (ARR-group) or three doses of RTS,S/AS01 (RRR-group) at months 0, 1, 2 followed by controlled human malaria infection. RESULTS: ARR and RRR vaccine re...

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Vydáno v:PLoS One
Hlavní autoři: Ockenhouse, Christian F., Regules, Jason, Tosh, Donna, Cowden, Jessica, Kathcart, April, Cummings, James, Paolino, Kristopher, Moon, James, Komisar, Jack, Kamau, Edwin, Oliver, Thomas, Chhoeu, Austin, Murphy, Jitta, Lyke, Kirsten, Laurens, Matthew, Birkett, Ashley, Lee, Cynthia, Weltzin, Rich, Wille-Reece, Ulrike, Sedegah, Martha, Hendriks, Jenny, Versteege, Isabella, Pau, Maria Grazia, Sadoff, Jerold, Vanloubbeeck, Yannick, Lievens, Marc, Heerwegh, Dirk, Moris, Philippe, Guerra Mendoza, Yolanda, Jongert, Erik, Cohen, Joe, Voss, Gerald, Ballou, W. Ripley, Vekemans, Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492580/
https://ncbi.nlm.nih.gov/pubmed/26148007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131571
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