Ad35.CS.01 - RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults

METHODS: In an observer blind, phase 2 trial, 55 adults were randomized to receive one dose of Ad35.CS.01 vaccine followed by two doses of RTS,S/AS01 (ARR-group) or three doses of RTS,S/AS01 (RRR-group) at months 0, 1, 2 followed by controlled human malaria infection. RESULTS: ARR and RRR vaccine re...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ockenhouse, Christian F., Regules, Jason, Tosh, Donna, Cowden, Jessica, Kathcart, April, Cummings, James, Paolino, Kristopher, Moon, James, Komisar, Jack, Kamau, Edwin, Oliver, Thomas, Chhoeu, Austin, Murphy, Jitta, Lyke, Kirsten, Laurens, Matthew, Birkett, Ashley, Lee, Cynthia, Weltzin, Rich, Wille-Reece, Ulrike, Sedegah, Martha, Hendriks, Jenny, Versteege, Isabella, Pau, Maria Grazia, Sadoff, Jerold, Vanloubbeeck, Yannick, Lievens, Marc, Heerwegh, Dirk, Moris, Philippe, Guerra Mendoza, Yolanda, Jongert, Erik, Cohen, Joe, Voss, Gerald, Ballou, W. Ripley, Vekemans, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492580/
https://ncbi.nlm.nih.gov/pubmed/26148007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131571
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