FOXM1 binds directly to non-consensus sequences in the human genome

BACKGROUND: The Forkhead (FKH) transcription factor FOXM1 is a key regulator of the cell cycle and is overexpressed in most types of cancer. FOXM1, similar to other FKH factors, binds to a canonical FKH motif in vitro. However, genome-wide mapping studies in different cell lines have shown a lack of...

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Bibliographic Details
Published in:Genome Biol
Main Authors: Sanders, Deborah A., Gormally, Michael V., Marsico, Giovanni, Beraldi, Dario, Tannahill, David, Balasubramanian, Shankar
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492089/
https://ncbi.nlm.nih.gov/pubmed/26100407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0696-z
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