Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration

BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of blindness. Most vision loss occurs following the transition from a disease of deposit formation and inflammation to a disease of neovascular fibrosis and/or cell death. Here, we investigate how repeated wound stimulus leads to...

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Détails bibliographiques
Publié dans:Genome Med
Auteurs principaux: Radeke, Monte J., Radeke, Carolyn M., Shih, Ying-Hsuan, Hu, Jane, Bok, Dean, Johnson, Lincoln V., Coffey, Pete J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491894/
https://ncbi.nlm.nih.gov/pubmed/26150894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0183-x
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