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Inflammation induces dermal Vγ4(+) γδT17 memory-like cells that travel to distant skin and accelerate secondary IL-17–driven responses
Gamma delta (γδ) T cells represent a major IL-17 committed T-cell population (γδT17 cells) in the mouse dermis. Following exposure to the inflammatory agent imiquimod (IMQ) the Vγ4(+) subset of γδT cells produce IL-17 in the skin and expand rapidly in draining lymph nodes (LNs). Local IMQ treatment...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491769/ https://ncbi.nlm.nih.gov/pubmed/26080440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508990112 |
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