Pivotal Role of Dermal IL-17-producing γδ T Cells in Skin Inflammation

Interleukin (IL)-23 and CD4(+) T helper-17 (Th17) cells are thought to be critical in the development of psoriasis. Here, we report that IL-23 predominantly stimulated dermal γδT cells to produce IL-17 that led to disease progression. Dermal γδT cells constitutively expressed the IL-23 receptor (IL-...

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Main Authors: Cai, Yihua, Shen, Xiaoyan, Ding, Chuanlin, Qi, Chunjian, Li, Kejia, Li, Xia, Jala, Venkatakrishna R., Zhang, Huang-ge, Wang, Tian, Zheng, Jie, Yan, Jun
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205267/
https://ncbi.nlm.nih.gov/pubmed/21982596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.08.001
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