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IL-17-committed Vγ4(+) γδ T cell deficiency in a spontaneous Sox13 mutant CD45.1 congenic mouse substrain protects from dermatitis

IL-17-committed γδ T (γδT17) cells participate in many immune responses but their developmental requirements and subset specific functions remain poorly understood. Here we report that a commonly used CD45.1(+) congenic C57BL/6 mouse substrain is characterized by a selective deficiency in Vγ4(+) γδT...

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Hlavní autoři: Gray, Elizabeth E., Ramírez-Valle, Francisco, Xu, Ying, Wu, Shuang, Wu, Zhihao, Karjalainen, Klaus E., Cyster, Jason G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660499/
https://ncbi.nlm.nih.gov/pubmed/23624556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2585
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