Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68

Pre-mRNA splicing is a complex regulatory nexus modulated by various trans-factors and their posttranslational modifications to create a dynamic transcriptome through alternative splicing. Signal-induced phosphorylation and dephosphorylation of trans-factors are known to regulate alternative splicin...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Nakka, Kiran Kumar, Chaudhary, Nidhi, Joshi, Shruti, Bhat, Jyotsna, Singh, Kulwant, Chatterjee, Subhrangsu, Malhotra, Renu, De, Abhijit, Santra, Manas Kumar, Dilworth, F. Jeffrey, Chattopadhyay, Samit
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491761/
https://ncbi.nlm.nih.gov/pubmed/26080397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418603112
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