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Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2

Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2. In the present study, we prepared twenty-one indeno[1,2-b]indole derivatives, all of which were tested in vitro on human CK2. The indenoindolo...

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Detalhes bibliográficos
Publicado no:Pharmaceuticals (Basel)
Main Authors: Alchab, Faten, Ettouati, Laurent, Bouaziz, Zouhair, Bollacke, Andre, Delcros, Jean-Guy, Gertzen, Christoph G.W., Gohlke, Holger, Pinaud, Noël, Marchivie, Mathieu, Guillon, Jean, Fenet, Bernard, Jose, Joachim, Le Borgne, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491662/
https://ncbi.nlm.nih.gov/pubmed/26061121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph8020279
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