DosS Is Required for the Complete Virulence of Mycobacterium tuberculosis in Mice with Classical Granulomatous Lesions

Mycobacterium tuberculosis (Mtb) must counter hypoxia within granulomas to persist. DosR, in concert with sensor kinases DosS and DosT, regulates the response to hypoxia. Yet Mtb lacking functional DosR colonize the lungs of C57Bl/6 mice, presumably owing to the lack of organized lesions with suffic...

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Dettagli Bibliografici
Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Gautam, Uma S., McGillivray, Amanda, Mehra, Smriti, Didier, Peter J., Midkiff, Cecily C., Kissee, Ryan S., Golden, Nadia A., Alvarez, Xavier, Niu, Tianhua, Rengarajan, Jyothi, Sherman, David R., Kaushal, Deepak
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2015
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491129/
https://ncbi.nlm.nih.gov/pubmed/25322074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0230OC
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