DosS Is Required for the Complete Virulence of Mycobacterium tuberculosis in Mice with Classical Granulomatous Lesions

Mycobacterium tuberculosis (Mtb) must counter hypoxia within granulomas to persist. DosR, in concert with sensor kinases DosS and DosT, regulates the response to hypoxia. Yet Mtb lacking functional DosR colonize the lungs of C57Bl/6 mice, presumably owing to the lack of organized lesions with suffic...

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Bibliographic Details
Published in:Am J Respir Cell Mol Biol
Main Authors: Gautam, Uma S., McGillivray, Amanda, Mehra, Smriti, Didier, Peter J., Midkiff, Cecily C., Kissee, Ryan S., Golden, Nadia A., Alvarez, Xavier, Niu, Tianhua, Rengarajan, Jyothi, Sherman, David R., Kaushal, Deepak
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491129/
https://ncbi.nlm.nih.gov/pubmed/25322074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0230OC
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