DosS Is Required for the Complete Virulence of Mycobacterium tuberculosis in Mice with Classical Granulomatous Lesions

Mycobacterium tuberculosis (Mtb) must counter hypoxia within granulomas to persist. DosR, in concert with sensor kinases DosS and DosT, regulates the response to hypoxia. Yet Mtb lacking functional DosR colonize the lungs of C57Bl/6 mice, presumably owing to the lack of organized lesions with suffic...

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Bibliografische gegevens
Gepubliceerd in:Am J Respir Cell Mol Biol
Hoofdauteurs: Gautam, Uma S., McGillivray, Amanda, Mehra, Smriti, Didier, Peter J., Midkiff, Cecily C., Kissee, Ryan S., Golden, Nadia A., Alvarez, Xavier, Niu, Tianhua, Rengarajan, Jyothi, Sherman, David R., Kaushal, Deepak
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Thoracic Society 2015
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491129/
https://ncbi.nlm.nih.gov/pubmed/25322074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0230OC
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