DosS Is Required for the Complete Virulence of Mycobacterium tuberculosis in Mice with Classical Granulomatous Lesions

Mycobacterium tuberculosis (Mtb) must counter hypoxia within granulomas to persist. DosR, in concert with sensor kinases DosS and DosT, regulates the response to hypoxia. Yet Mtb lacking functional DosR colonize the lungs of C57Bl/6 mice, presumably owing to the lack of organized lesions with suffic...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Gautam, Uma S., McGillivray, Amanda, Mehra, Smriti, Didier, Peter J., Midkiff, Cecily C., Kissee, Ryan S., Golden, Nadia A., Alvarez, Xavier, Niu, Tianhua, Rengarajan, Jyothi, Sherman, David R., Kaushal, Deepak
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491129/
https://ncbi.nlm.nih.gov/pubmed/25322074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0230OC
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