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Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors

Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit th...

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Bibliografiske detaljer
Udgivet i:Protein Cell
Main Authors: Dong, Yu, Qiu, Xiaodi, Shaw, Neil, Xu, Yueyang, Sun, Yuna, Li, Xuemei, Li, Jun, Rao, Zihe
Format: Artigo
Sprog:Inglês
Udgivet: Higher Education Press 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491049/
https://ncbi.nlm.nih.gov/pubmed/26081470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-015-0181-1
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