Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors

Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit th...

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Detalhes bibliográficos
Publicado no:Protein Cell
Main Authors: Dong, Yu, Qiu, Xiaodi, Shaw, Neil, Xu, Yueyang, Sun, Yuna, Li, Xuemei, Li, Jun, Rao, Zihe
Formato: Artigo
Idioma:Inglês
Publicado em: Higher Education Press 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491049/
https://ncbi.nlm.nih.gov/pubmed/26081470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-015-0181-1
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