Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors

Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit th...

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Vydáno v:Protein Cell
Hlavní autoři: Dong, Yu, Qiu, Xiaodi, Shaw, Neil, Xu, Yueyang, Sun, Yuna, Li, Xuemei, Li, Jun, Rao, Zihe
Médium: Artigo
Jazyk:Inglês
Vydáno: Higher Education Press 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491049/
https://ncbi.nlm.nih.gov/pubmed/26081470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-015-0181-1
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