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The Importance of Interleukin-6 in the Development of LAT-mediated Autoimmunity
LAT (linker for activation of T cells) is a transmembrane adaptor protein that is highly tyrosine phosphorylated upon engagement of the T cell receptor (TCR). Phosphorylated LAT binds Grb2, Gads, and PLCγ1 to mediate T cell activation, proliferation, and cytokine production. T cells from mice harbor...
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| Publicat a: | J Immunol |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491041/ https://ncbi.nlm.nih.gov/pubmed/26034173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1403187 |
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