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Innate Immunity at Mucosal Surfaces: the IRE1-RIDD-RIG-I Pathway
Recent studies have linked the ER stress sensor IRE1α with the RIG-I pathway, which triggers an inflammatory response upon detection of viral RNAs. In response to ER dysfunction, IRE1α cleaves mRNA into single-strand fragments that lack markers of self, which activate RIG-I. Certain microbial produc...
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| Publicado en: | Trends Immunol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4490948/ https://ncbi.nlm.nih.gov/pubmed/26093676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2015.05.006 |
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