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Combining progression-free survival and overall survival as a novel composite endpoint for glioblastoma trials

BACKGROUND: The use of auxiliary endpoints may provide efficiencies for clinical trial design, but such endpoints may not have intrinsic clinical relevance or clear linkage to more meaningful endpoints. The purpose of this study was to generate a novel endpoint that considers both overall survival (...

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Publicado en:Neuro Oncol
Main Authors: Trippa, Lorenzo, Wen, Patrick Y., Parmigiani, Giovanni, Berry, Donald A., Alexander, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490868/
https://ncbi.nlm.nih.gov/pubmed/25568226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou345
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