Combining progression-free survival and overall survival as a novel composite endpoint for glioblastoma trials

BACKGROUND: The use of auxiliary endpoints may provide efficiencies for clinical trial design, but such endpoints may not have intrinsic clinical relevance or clear linkage to more meaningful endpoints. The purpose of this study was to generate a novel endpoint that considers both overall survival (...

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Vydáno v:Neuro Oncol
Hlavní autoři: Trippa, Lorenzo, Wen, Patrick Y., Parmigiani, Giovanni, Berry, Donald A., Alexander, Brian M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Clinical Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490868/
https://ncbi.nlm.nih.gov/pubmed/25568226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou345
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