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Detecting an Overall Survival Benefit that Is Derived From Progression-Free Survival

BACKGROUND: Whether progression-free survival (PFS) or overall survival (OS) is the more appropriate endpoint in clinical trials of metastatic cancer is controversial. In some disease and treatment settings, an improvement in PFS does not result in an improved OS. METHODS: We partitioned OS into two...

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Detalhes bibliográficos
Main Authors: Broglio, Kristine R., Berry, Donald A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137232/
https://ncbi.nlm.nih.gov/pubmed/19903805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djp369
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