Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

CDK9 is the kinase subunit of positive transcription elongation factor b (P-TEFb) that enables RNA polymerase (Pol) II's transition from promoter-proximal pausing to productive elongation. Although considerable interest exists in CDK9 as a therapeutic target, little progress has been made due t...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lu, Huasong, Xue, Yuhua, Yu, Guoying K, Arias, Carolina, Lin, Julie, Fong, Susan, Faure, Michel, Weisburd, Ben, Ji, Xiaodan, Mercier, Alexandre, Sutton, James, Luo, Kunxin, Gao, Zhenhai, Zhou, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490784/
https://ncbi.nlm.nih.gov/pubmed/26083714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06535
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