Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases

Methylation of histone H3 lysine-4 (H3K4) is an important, regulatory, epigenetic post-translational modification associated with actively transcribed genes. In humans, the principal mediators of this modification are part of the MLL/SET1 family of methyltransferases, which comprises six members, ML...

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Detalhes bibliográficos
Publicado no:Assay Drug Dev Technol
Main Authors: Ferry, Joseph J., Smith, Robert F., Denney, Natalie, Walsh, Colin P., McCauley, Lauren, Qian, Jie, Ma, Haiching, Horiuchi, Kurumi Y., Howitz, Konrad T.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490707/
https://ncbi.nlm.nih.gov/pubmed/26065558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2015.646
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