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Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells

Autophagy is an important stress response pathway responsible for the removal and recycling of damaged or redundant cytosolic constituents. Mitochondrial damage triggers selective mitochondrial autophagy (mitophagy), mediated by a variety of response factors including the Pink1/Parkin system. Using...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: MacVicar, Thomas D. B., Mannack, Lilith V. J. C., Lees, Robert M., Lane, Jon D.
Format: Artigo
Langue:Inglês
Publié: MDPI 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490499/
https://ncbi.nlm.nih.gov/pubmed/26110381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms160613356
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