Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

Intravascular hemolysis describes the relocalization of heme and hemoglobin (Hb) from erythrocytes to plasma. We investigated the concept that erythrocyte membrane microparticles (MPs) concentrate cell-free heme in human hemolytic diseases, and that heme-laden MPs have a physiopathological impact. U...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Camus, Stéphane M., De Moraes, João A., Bonnin, Philippe, Abbyad, Paul, Le Jeune, Sylvain, Lionnet, François, Loufrani, Laurent, Grimaud, Linda, Lambry, Jean-Christophe, Charue, Dominique, Kiger, Laurent, Renard, Jean-Marie, Larroque, Claire, Le Clésiau, Hervé, Tedgui, Alain, Bruneval, Patrick, Barja-Fidalgo, Christina, Alexandrou, Antigoni, Tharaux, Pierre-Louis, Boulanger, Chantal M., Blanc-Brude, Olivier P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490297/
https://ncbi.nlm.nih.gov/pubmed/25827830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-589283
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