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Sickle cell vasoocclusion and rescue in a microfluidic device

The pathophysiology of sickle cell disease is complicated by the multiscale processes that link the molecular genotype to the organismal phenotype: hemoglobin polymerization occurring in milliseconds, microscopic cellular sickling in a few seconds or less [Eaton WA, Hofrichter J (1990) Adv Protein C...

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Detalhes bibliográficos
Main Authors: Higgins, J. M., Eddington, D. T., Bhatia, S. N., Mahadevan, L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154459/
https://ncbi.nlm.nih.gov/pubmed/18077341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707122105
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