Pharmacokinetic Evaluation of the Equivalency of Gavage, Dietary, and Drinking Water Exposure to Manganese in F344 Rats

Concerns exist as to whether individuals may be at greater risk for neurotoxicity following increased manganese (Mn) oral intake. The goals of this study were to determine the equivalence of 3 methods of oral exposure and the rate (mg Mn/kg/day) of exposure. Adult male rats were allocated to control...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Toxicol Sci
Egile Nagusiak: Foster, Melanie L., Bartnikas, Thomas B., Johnson, Laura C., Herrera, Carolina, Pettiglio, Michael A., Keene, Athena M., Taylor, Michael D., Dorman, David C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2015
Gaiak:
Pharmacokinetic Modeling of Manganese
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490190/
https://ncbi.nlm.nih.gov/pubmed/25724921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv047
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