Pharmacokinetic Evaluation of the Equivalency of Gavage, Dietary, and Drinking Water Exposure to Manganese in F344 Rats

Concerns exist as to whether individuals may be at greater risk for neurotoxicity following increased manganese (Mn) oral intake. The goals of this study were to determine the equivalence of 3 methods of oral exposure and the rate (mg Mn/kg/day) of exposure. Adult male rats were allocated to control...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Foster, Melanie L., Bartnikas, Thomas B., Johnson, Laura C., Herrera, Carolina, Pettiglio, Michael A., Keene, Athena M., Taylor, Michael D., Dorman, David C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Pharmacokinetic Modeling of Manganese
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490190/
https://ncbi.nlm.nih.gov/pubmed/25724921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv047
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