A novel cinnamon-related natural product with Pim-1 inhibitory activity inhibits leukemia and skin cancer

The Pim-1 kinase regulates cell survival, proliferation and differentiation and is overexpressed frequently in many malignancies including leukemia and skin cancer. In this study, we used kinase profiling analysis to demonstrate that 2′-hydroxycinnamicadelhyde (2′-HCA), a compound found in cinnamon,...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Kim, Jong-Eun, Son, Joe Eun, Jeong, Hyein, Joon Kim, Dong, Seo, Sang Kwon, Lee, Eunjung, Lim, Tae Gyu, Kim, Jong Rhan, Chen, Hanyong, Bode, Ann M., Lee, Ki Won, Dong, Zigang
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490130/
https://ncbi.nlm.nih.gov/pubmed/25948588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3655
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