A novel cinnamon-related natural product with Pim-1 inhibitory activity inhibits leukemia and skin cancer

The Pim-1 kinase regulates cell survival, proliferation and differentiation and is overexpressed frequently in many malignancies including leukemia and skin cancer. In this study, we used kinase profiling analysis to demonstrate that 2′-hydroxycinnamicadelhyde (2′-HCA), a compound found in cinnamon,...

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Dettagli Bibliografici
Pubblicato in:Cancer Res
Autori principali: Kim, Jong-Eun, Son, Joe Eun, Jeong, Hyein, Joon Kim, Dong, Seo, Sang Kwon, Lee, Eunjung, Lim, Tae Gyu, Kim, Jong Rhan, Chen, Hanyong, Bode, Ann M., Lee, Ki Won, Dong, Zigang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490130/
https://ncbi.nlm.nih.gov/pubmed/25948588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3655
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