A novel cinnamon-related natural product with Pim-1 inhibitory activity inhibits leukemia and skin cancer

The Pim-1 kinase regulates cell survival, proliferation and differentiation and is overexpressed frequently in many malignancies including leukemia and skin cancer. In this study, we used kinase profiling analysis to demonstrate that 2′-hydroxycinnamicadelhyde (2′-HCA), a compound found in cinnamon,...

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Vydáno v:Cancer Res
Hlavní autoři: Kim, Jong-Eun, Son, Joe Eun, Jeong, Hyein, Joon Kim, Dong, Seo, Sang Kwon, Lee, Eunjung, Lim, Tae Gyu, Kim, Jong Rhan, Chen, Hanyong, Bode, Ann M., Lee, Ki Won, Dong, Zigang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490130/
https://ncbi.nlm.nih.gov/pubmed/25948588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3655
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