PTD-Modified ATTEMPTS for Enhanced Toxin-based Cancer Therapy: An In Vivo Proof-of-Concept Study

PURPOSE: To investigate the feasibility of applying PTD-modified ATTEMPTS (Antibody Targeted Triggered Electrically Modified Prodrug-Type Strategy) for enhanced toxin therapy for the treatment of cancer. METHODS: A heparin-functionalized murine anti-CEA monoclonal antibody (mAb), T84.66-heparin (T84...

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發表在:Pharm Res
Main Authors: Shin, Meong Cheol, Zhang, Jian, Min, Kyoung Ah, He, Huining, David, Allan E., Huang, Yongzhuo, Yang, Victor C.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490053/
https://ncbi.nlm.nih.gov/pubmed/25701313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1653-y
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