Preparation and Characterization of Gelonin-Melittin Fusion Biotoxin for Synergistically Enhanced Anti-Tumor Activity

PURPOSE: To investigate the applicability of fusion biotoxins combining pore-forming toxins (PFTs) and ribosome-inactivating proteins (RIPs) for the anti-cancer treatment. METHODS: Membrane active PFTs tend to destabilize cell membranes of tumor cells, but lack a warhead inducing significant cause o...

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Vydáno v:Pharm Res
Hlavní autoři: Shin, Meong Cheol, Min, Kyoung Ah, Cheong, Heesun, Moon, Cheol, Huang, Yongzhuo, He, Huining, Yang, Victor C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967393/
https://ncbi.nlm.nih.gov/pubmed/27251414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-1959-4
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