K562-Derived Whole-Cell Vaccine Enhances Antitumor Responses of CAR-Redirected Virus-Specific Cytotoxic-T Lymphocytes in vivo

PURPOSE: Adoptive transfer of Epstein Barr Virus (EBV)- and Cytomegalovirus (CMV)-specific cytotoxic T cells (CTLs) genetically modified to express a Chimeric Antigen Receptor (CAR) induces objective tumor responses in clinical trials. In vivo expansion and persistence of these cells is crucial to a...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Caruana, Ignazio, Weber, Gerrit, Ballard, Brandon Corde’, Wood, Michael Scott, Savoldo, Barbara, Dotti, Gianpietro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490027/
https://ncbi.nlm.nih.gov/pubmed/25691731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2998
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