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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T-lymphocytes
Adoptive transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less striking effects in solid tumors(1–3) than in lymphoid malignancies(4, 5). Although active tumor-mediated immunosuppression may play a role in limiting efficacy(6), functional changes in T lympho...
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| I publikationen: | Nat Med |
|---|---|
| Huvudupphovsmän: | , , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4425589/ https://ncbi.nlm.nih.gov/pubmed/25849134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3833 |
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