Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T-lymphocytes

Adoptive transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less striking effects in solid tumors(1–3) than in lymphoid malignancies(4, 5). Although active tumor-mediated immunosuppression may play a role in limiting efficacy(6), functional changes in T lympho...

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Bibliografiska uppgifter
I publikationen:Nat Med
Huvudupphovsmän: Caruana, Ignazio, Savoldo, Barbara, Hoyos, Valentina, Weber, Gerrit, Liu, Hao, Kim, Eugene S., Ittmann, Michael M., Marchetti, Dario, Dotti, Gianpietro
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425589/
https://ncbi.nlm.nih.gov/pubmed/25849134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3833
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