Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3ζ in Human T Cells

T lymphocytes from many patients with systemic lupus erythematosus (SLE) express decreased levels of the T cell receptor (TCR)-associated CD3 zeta (ζ) signaling chain, a feature directly linked to their abnormal phenotype and function. Reduced mRNA expression partly due to defective alternative spli...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Moulton, Vaishali R., Gillooly, Andrew R., Perl, Marcel A., Markopoulou, Anastasia, Tsokos, George C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489909/
https://ncbi.nlm.nih.gov/pubmed/26134847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131073
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